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    现在位置首页>技术资料首页>行业动态>公司动态>安捷伦与Covaris合作开发新一代测序市场

    安捷伦与Covaris合作开发新一代测序市场

    安捷伦2010年1月21日 15:09 点击:2943

    安捷伦 Agilent.  美国Covaris

    TRADE NEWS: 安捷伦科技公司与Covaris公司签署了合作开发市场协议将靶向序列富集与DNA剪切技术结合用于新一代测序分析
      
        201015日报道——安捷伦科技公司(NYSE: A)Covaris 公司于今日宣布了签订一项合作开发市场协议,该协议表明,未来Covaris S2 DNA剪切技术将与安捷伦 SureSelect 靶向序列捕获系统一起销售以提高新一代测序实验的效率。
         “Covaris
    公司提供了一种非常重要的样?#20998;?#22791;工具。它可以均匀地剪切DNA,并且已经被全世界顶尖研?#31354;?#29992;于新一代的测序分析中,安捷伦新型基因组学应用产品经理Fred Ernani博士说,随着越来越多的研?#31354;?#24320;始认识到SureSelect 靶向序列捕获系统的价值,他们会发现将这种技术与Covaris公司的DNA剪切技术结合具有更加广阔的应用前景。
         
    “Covaris公司很高兴与安捷伦科技公司签署这项合作开发市场协议,作为生命科学产业的领导者,安捷伦科技公司认识到了控制样?#20998;?#22791;过程对于在复杂的靶标选择应用中确保结果质量的重要性 Covaris公司总裁兼首席执行官 Jim Laugharn说,目前高级生物应用的相关数据结果正在呈现指数?#23545;?#38271;。由于对相关数据结果的要求更加?#37327;蹋?#20127;须一种工程化的样?#20998;?#22791;程序来控制起始样品的质量。我们盼望与安捷伦的合作能够为SureSelect的全球用户带来高质量的样?#20998;?#22791;过程。
         
    20092月份推出的安捷伦SureSelect靶向序列捕获系统极大地提高了生命科学研究中新一代测序工作流程的速度和成本效益,它使研?#31354;?#33021;够把精力集中在他们?#34892;?#36259;的基因组区域而无需进行全基因组测序。这个安捷伦捕获系统不同于其他同类产?#20998;?#22788;在于,它是基于溶液体系设计的,易于实现自动化,并且扩展性强,很容易从十个反应的小型系统扩展到几千个反应的大规模系?#22330;?br />    安捷伦的靶向序列捕获产品线提供多达55000 种生物素标记的RNA探针,可由用户自由指定混合成单管运输。捕捉探针的长度是120个碱基对,这是目前市场上同类产?#20998;?#26368;长的。这使得该探针在捕捉含有DNA的未知突变,如单核苷酸多态性,插入突变或者缺失突变时非常?#34892;А?#29992;户可以利用安捷伦eArray在线设计工具自行设计需要的 SureSelect探针库,这个工具中包含了很多关键的基因组,并?#20197;市?#23458;户上传他们自己的序列。这种直观的基于网页的设计工具是安捷伦定制基因产品生产能力的核心,并且已经扩展到了新的SureSelect平台。eArray?#24066;?#30740;?#31354;?#24456;容易的设计他们所需要的工具,而不需要预?#24230;?#20309;设计费用。

    Covaris样?#20998;?#22791;技术是基于获得专利的Adaptive Focused Acoustic (AFA) 技术,提高了生物和化学样?#20998;?#22791;的速度和效率。Covaris样?#20998;?#22791;方法为新一代测序工作流程提供一种高度可预测和可重复的DNA剪切方法,同时减少了剪切过程中DNA样品的损失,从而加速了新一代DNA测序样?#20998;?#22791;过程。

    因为新一代测序工作流程很复杂,并且不样品失败代价很大,所以安捷伦使用最佳的方案来开发SureSelect操作流程 Ernani说,Covaris的剪切技术与我们的方法相结合意义重大。到目前为止,SureSelect的用户发现我们的方法简便易行,并且非常用,所以我相信推荐使用Covaris S2是一个很好的选择。

    作为合作开发市场协议的一部分, Covaris开发了一种特殊的SureSelect配?#36164;?#21058;盒以帮助用户将这种技术融入到他们的工作流程中去。这使SureSelect用户选择购买Covaris S2系统变得更有价值。安捷伦将会继续与Covaris合作开发新的SureSelect操作流程和产品,进一步提升两种产品的优势,为新一代测序使用者提供了最好的靶向重测序工具。
         
    如需了解安捷伦SureSelect 靶向序列捕获系统的更多信息,访问www.opengenomics.com/SureSelect 。查询eArray请访问 https://earray.chem.agilent.com

     

    关于Covaris公司
    Covaris公司是一家快速成长的生命科学仪器公司。它特有的仪器平台基于专利Adaptive Focused Acoustic (AFA)技术,为生物和化学样?#20998;?#22791;带来了无与伦比的速度和效率。基于冲击波物理的AFA技术,能将能量精准地传输到生物和化学样品。整个过程具有非接触、恒?#24405;?#24555;速的特点。全球领先的药物和生物技术公司都在使用Covaris的仪器用于RNA提取、化合物溶解、药物代谢物的组织提取以?#38774;?#22810;其他应用。Covaris公司在全球超过25个国家销售了1000多台仪器。关于Covaris公司的更多信息,请访问:www.covarisinc.com

    关于安捷伦科技公司
    安捷伦科技公司(NYSE: A)是世界上领先的测量测试公司和技术领导者,涉及通信,电子,生命科学和化学分析。公司的17,000员工为遍及世界110多个国?#19994;目?#25143;提供优质服务。安捷伦2009年的净收入为45亿美元。关于安捷伦的更多信息,请访问www.agilent.com

                                               # # #
    进一步的技术,企业公民的职责和权利及行政的新闻请访问安捷伦新闻网站www.agilent.com/go/news

    Agilent Technologies 新闻稿
    Agilent Technologies and Covaris Sign Co-Marketing Agreement Pairing Target Enrichment with DNA Shearing for Next-Gen Sequencing
     

    SANTA CLARA, Calif. and WOBURN, Mass., Jan. 5, 2010

    Agilent Technologies, Inc. (NYSE: A) and Covaris Inc. today announced a co-marketing agreement in which Covaris S2 DNA shearing technology will be marketed with the Agilent SureSelect Target Enrichment System to streamline next-generation sequencing experiments.

    "Covaris provides an important sample preparation tool for shearing DNA evenly, and it has been adopted by next-generation sequencing thought leaders around the world," said Fred Ernani, Ph.D., Agilent senior product manager for Emerging Genomic Applications. "As increasing numbers of investigators recognize the value of the SureSelect Target Enrichment System, they see even more value in combining it with Covaris' DNA shearing technology."

    "Covaris is pleased to enter into this co-marketing arrangement with Agilent Technologies, a life sciences industry leader that recognizes the importance of controlling sample preparation to ensure quality results in sophisticated target selection applications," said Jim Laugharn, Covaris president and CEO. "Advanced biological applications are currently experiencing exponential growth in data set output. Given this high level of production, it is even more critical to provide an engineered sample preparation process to control the quality of the starting material. We look forward to working with Agilent to bring high-quality sample preparation to SureSelect customers on a global basis."

    The Agilent SureSelect Target Enrichment System, introduced in February 2009, has been shown to greatly increase the speed and cost-efficiency of next-generation sequencing workflows used in life science research by enabling researchers to focus on genomic regions of interest rather than sequencing the entire genome. The Agilent system is based on an in-solution design, making it automation-friendly and easily scalable from 10 reactions through thousands, unlike other commercially available products for this application.

    Agilent's target-enrichment product line offers customer-specified mixtures of up to 55,000 biotinylated RNA probes, delivered in single tubes. The capture probes are 120 base pairs long, the longest currently on the market for this application. This makes the probes very effective at capturing DNA-containing unknown mutations, such as single nucleotide polymorphisms, insertions or deletions.

    Users can design their own custom SureSelect mixtures using the Agilent eArray online design tool, which contains many key genomes and also lets users upload their own sequences. This intuitive, Web-based design tool is the heart of Agilent's custom genomics product manufacturing capability and has now been expanded to the newer SureSelect platforms. eArray allows researchers to easily design the tools they need without up-front design fees.

    The Covaris sample preparation technology, which is based on its patented Adaptive Focused Acoustic (AFA) technology, brings speed and efficiency to biological and chemical sample preparation. The Covaris method accelerates next-generation DNA sequencing sample preparation by providing a highly predictable and reproducible DNA shearing methodology to the next-gen workflow while limiting the amount of sample DNA lost in the shearing process.

    "Since next-generation sequencing workflows are complex and sample failure is costly, Agilent chose to develop its SureSelect protocols using best practice," Ernani said. "Incorporating Covaris' shearing into our protocols made the most sense. So far, SureSelect customers have found our protocols to be very easy to follow and extremely robust, so I believe we've made a good choice to recommend the use of the Covaris S2."

    As part of the co-marketing agreement, Covaris has developed a special SureSelect Accessory Kit to help customers integrate the technology into their workflows. This adds significant value for SureSelect customers who choose to buy Covaris S2 systems. Agilent will continue to work with Covaris to develop new SureSelect protocols and products, leveraging the benefits of both products to provide next-generation sequencing users with the most robust tools for targeted re-sequencing.

    About Covaris, Inc.

    Covaris, Inc. is a rapidly growing life science instrument company. Its proprietary instrument platform, based on patented Adaptive Focused Acoustic (AFA) technology brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, based on shock wave physics, delivers controlled, precise and accurate energy to biological and chemical samples. The process is non-contact, isothermal, and rapid. Leading pharmaceutical and biotechnology companies worldwide are using Covaris instruments for RNA extraction, compound dissolution, drug metabolism tissue extraction, and much more. Covaris has sold more than 1,000 instruments in more than 25 countries around the world. Information about Covaris is available at www.covarisinc.com.


    About Agilent Technologies

    Agilent Technologies Inc. (NYSE: A) is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 17,000 employees serve customers in more than 110 countries. Agilent had net revenues of $4.5 billion in fiscal 2009. Information about Agilent is available on the Web at www.agilent.com.

    # # #

    Contact:

    Stuart Matlow, Agilent
    +1 408 553 7191
    [email protected]

    Brian Paras, Covaris
    +1 781 932 3959 Ext. 206
    [email protected]

     

    (来源: 安捷伦 )


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