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    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    现在位置首页>技术资料首页>行业动态>行业动态>利用生物标记作生物芯片及微阵列检查的最新动向:崭新的技术、成长的机会、未来的观察?#33455;?#25253;告

    利用生物标记作生物芯片及微阵列检查的最新动向:崭新的技术、成长的机会、未来的观察?#33455;?#25253;告

    互联网2010年1月8日 14:42 点击:3342

    利用生物标记作生物芯片及微阵列检查的最新动向:崭新的技术、成长的机会、未来的观察?#33455;?#25253;告——Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative technologies, growth opportunities and the future market outlook
    Abstract
    Microarrays and biochips are small devices capable of detecting and measuring large numbers of biomarkers simultaneously. Although microarrays have been in research use for over a decade it is only recently that they have moved towards meeting the requirements of the clinical and regulatory communities with the first DNA microarray test being approved by the US FDA in 2007. Further development of microarrays heralds the introduction of faster diagnosis times and will further enable personalized medicine. This report covers future developments in key segments of the microarray market including DNA, protein, tissue and cell microarrays and lab-on-a-chip technologies, providing market forecasts to 2013. In addition the report gives insights into the developmental programs of 45 leading players in this market.

    Table of Contents
    Executive Summary
    Biochips, biomarkers, and in vitro diagnostics
    DNA microarrays
    Protein microarrays
    Tissue and cell microarrays
    Lab-on-a-Chip technologies
    Biochip companies
    Market Analysis and Forecasts
    Chapter 1 Biochips, biomarkers, and in vitro diagnostics
    Summary
    Biomarker-based IVDs
    Introduction to biochips
    Microarrays
    Microfluidic chips
    Background on nucleic acid and protein testing
    Immunoassay technology
    Immunoassay formats
    Rapid immunochromatographic assays
    Multiplexed assays
    Nucleic acid testing
    Probe-based NAT
    Amplification technologies
    Biomarker discovery and validation
    Translating biomarkers into IVDs
    Regulation of in vitro diagnostics
    Europe
    USA
    Draft guidance on multivariate analysis
    Chapter 2 DNA microarrays
    Summary
    Introduction
    DNA microarray fabrication technologies
    Standard microarrays
    3-D DNA microarrays
    Particle (bead)-based microarrays
    Analytical uses of DNA microarrays
    SNP genotyping
    Detection of genetic imbalances
    Gene expression profiling
    Single-channel microarrays
    Two-channel microarrays
    Methods utilizing RT-PCR
    MicroRNA expression profiling
    Limitations and barriers to commercialization
    Key commercial players
    DNA microarray testing in cancer
    Overview
    Progress in breast cancer
    Early detection
    Classification, prognosis, and treatment
    Tumors of unidentified origin
    Other advances
    DNA microarray testing in genetic disorders
    Microarrays testing for adverse drug reactions
    DNA microarray testing in transplant management
    DNA microarray testing in other conditions
    Expanding applications
    Chapter 3 Protein microarrays
    Summary
    Introduction
    Background on proteomics
    Protein microarray technologies
    Formats
    Glass slides
    Microwell/nanowell chips
    Implementation
    3.3.2.1 Forward-phase microarrays
    Prospects for multiplex ELISAs
    Reverse-phase microarrays
    Detection of bound targets
    SELDI ProteinChip technology
    Fabrication technologies
    Dispensing technology
    Protein immobilization strategies
    Surface chemistries
    Analytical uses of protein microarrays
    Commercial microarrays for clinical research
    Protein microarray diagnostics in cancer
    Chapter 4 Tissue and cell microarrays
    Summary
    Introduction
    Tissue microarrays
    Advantages
    Construction
    Sources of tissue
    Scanning and analysis
    Companies providing products and services
    Uses of tissue microarrays
    Clinical investigations in cancer
    Initiatives using cell microarrays
    Overview
    Examples of diagnostic applications
    Chapter 5 Lab-on-a-Chip Technologies
    Summary
    Introduction to microfluidics
    Lab-on-a-chip devices
    Construction methods
    Companies and technologies
    Multiplexed particle assays
    Multiplexing at the microlevel
    Particle encoding technologies
    Applications of LoC devices
    Changing diagnostics
    Future role in PoC testing
    Chapter 6 Biochip companies
    Introduction/Summary
    Accelr8 Technology Corporation
    Company description
    Microarray-based rapid bacterial analysis
    Advanced Liquid Logic Inc
    Company description
    Digital Microfluidics devices
    Affymetrix Inc
    Company description
    DNA and protein microarrays
    Agendia BV
    Company description
    Gene expression microarray diagnostics
    MammaPrint
    TargetPrint
    CupPrint
    ColoPrint
    Agilent Technologies Inc
    Company description
    DNA microarrays
    Almac Group Ltd
    Company description
    Microarray-based gene expression profiling
    Ambry Genetics Corp
    Company description
    Microarray-based cytogenetic testing
    Applied Microarrays Inc
    Company description
    3-D DNA microarrays
    Arrayit Corp
    Company description
    Universal DNA microarray-based diagnostics
    ArrayXpress Inc
    Company description
    Microarray services
    Atactic Technologies Inc
    Company description
    Specialty microarrays
    Aushon BioSystems Inc
    Company description
    Protein microarrays and services
    AutoGenomics Inc
    Company description
    3-D DNA microarrays for diagnostics
    Beecher Instruments Inc
    Company description
    Tisue microarray products and services
    BioArray Solutions Ltd
    Company description
    Bead-based microfluidic arrays
    BioDot Inc
    Company description
    Protein biochip manufacture
    Caliper Life Sciences Inc
    Company description
    Microfluidic lab-on-a-chip systems
    CapitalBio Corp
    Company description
    Microarray systems and diagnostics
    CombiMatrix Corp
    Company description
    DNA microarray technology and diagnostics
    Cybrdi Inc
    Company description
    Tissue microarray products and services
    Decision Biomarkers Inc
    Company description
    Microarrays for multiplex immunoassays
    Epigenomics AG
    Company description
    Methylation microarrays for diagnostics
    ExonHit Therapeutics SA
    Company description
    Differential gene expression profiling
    Expression Analysis Inc
    Company description
    DNA microarray-based testing services
    GeneNews Ltd
    Company description
    Gene expression diagnostics
    GenTel BioSciences Inc
    Company description
    Protein microarrays and research kits
    Illumina Inc
    Company description
    Bead-based microarrays
    Imgenex Corp
    Company description
    Tissue microarrays
    Iris BioTechnologies Inc
    Company description
    DNA microarrays for diagnostic profiling
    LC Sciences LLC
    Company description
    Microarray products and services
    Life Technologies Corp
    Company description
    Microarray/microfluidic research tools
    Luminex Corp
    Company description
    Bead suspension microarrays and diagnostics
    Maxwell Sensors Inc
    Company description
    Microarray and microfluidic products
    Med BioGene Inc
    Company description
    Gene expression microarrays for diagnosis
    Micronics Inc
    Company description
    Disposable microfluidic diagnostic labcards
    Micronit Microfluidics BV
    Company description
    Microfluidic glass chips
    Oxford Gene Technology Ltd
    Company description
    DNA and protein microarrays
    Protein BioTechnologies Inc
    Company description
    Protein and tissue microarrays
    Response Genetics Inc
    Company description
    Microarray gene expression cancer testing
    Roche NimbleGen Inc
    Company description
    DNA microarray products and services
    SABiosciences Corp
    Company description
    DNA microarrays and RT-PCR arrays
    Signature Genomic Laboratories LLC
    Company description
    Microarray-based cytogenetic diagnostics
    SomaLogic Inc
    Company description
    Aptamer microarrays
    US Biomax Inc
    Company description
    Tissue microarrays
    Xceed Molecular Corp
    Company description
    3-D DNA microarrays
    Chapter 7 Market analysis and forecasts
    Summary
    Introduction
    DNA microarray review
    Market history
    Some leading players
    Market growth
    Protein microarray review
    Market history
    Some leading players
    Market growth
    Market segmentation and forecasts
    Market prospects
    Chapter 8 Appendix 1 Abbreviations and Acronyms
    Scientific/technical/medical terms
    A2.2 Institutional/regulatory terms
    Chapter 9 Appendix 2 Research Methodology
    Index
    List of Figures
    Figure 1.1: Non-competitive "sandwich" assay
    Figure 2.2: An approx 18,000-test gene microarray
    Figure 3.3: Principle of a spatially addressable protein microarray
    List of Tables
    Table 2.1: Companies featured in Chapter 2
    Table 2.2: DNA microarray technologies/products
    Table 2.3: Systems for gene expression profiling
    Table 2.4: Gene expression tests in breast cancer
    Table 2.5: Other cancer tests
    Table 2.6: DNA microarray testing in genetic disorders
    Table 3.7: Companies featured in Chapter 3
    Table 3.8: Protein microarray technologies/products
    Table 3.9: Protein microarrays for clinical research
    Table 3.10: Protein microarray-enabled cancer diagnostic discovery
    Table 4.11: Companies and products featured in Chapter 4
    Table 5.12: Companies and products featured in Chapter 5
    Table 7.13: Microarray Industry Bibliometric Output, 2000-2008
    Table 7.14: Snapshot of FDA approved in vitro diagnostic microarray products
    Table 7.15: Microarray Forecasts ($m)
    Table 7.16: Leading Company Market Shares
    微阵列和生物芯片可以同时探知、测定很多生物标记。但是近10年间只用在?#33455;?#30340;微阵列在2007年美国FDA认定后,在开发上有很大的迈进。缩短诊断时间及个别化医疗的可能性都值得期待。

    本报告书内容包含:DNA及蛋白质、组织和细胞、实验室芯片等微阵列市场的各区块概要和到2013年为止的市场预测、介绍进攻市场的45间大公司的开发案。内容纲要摘记如下:

    实施概要
    第1章 生物芯片、生物标记、体外诊断
    摘要
    生物标记的体外诊断
    生物芯片的介绍
    核酸和蛋白质检查的概要
    生物标记的发现和评价
    生物标记的体外诊断的发展
    体外诊断的法规限制
    第2章 DNA微阵列
    摘要
    介绍
    DNA微阵列制造技术
    DNA微阵列分析的利用
    癌症的DNA微阵列检查
    基因病患的DNA微阵列检查
    药剂副作用的微阵列检查
    移植管理所需的微阵列检查
    其他状况的微阵列检查
    用途扩大
    第3章 蛋白质微阵列
    摘要
    介绍
    蛋白体学概要
    蛋白质微阵列技术
    蛋白质微阵列的活用
    ?#37995;?#34507;白质微阵列的临床?#33455;?#20351;用
    癌症诊断用蛋白质微阵列
    第4章 组织?细胞微阵列
    摘要
    介绍
    组织微阵列
    细胞微阵列的比较
    第5章 实验室芯片技术
    摘要
    介绍
    实验室芯片
    多重粒子分析
    实验室芯片设备的应用
    第6章 生物芯片企业
    第7章 市场分析和预测
    摘要
    介绍
    DNA微阵列的の评估
    蛋白质微阵列的评估
    市场区块化和预测
    市场观察
    第8章 附录1:缩写字解説
    第9章 附录2:调查方法
    图表

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