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    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    商品编号:73572
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    Calcein AM MG1998-1mg

    价    格:1350

    产    地:上海更新时间:

    品    牌:迈基生物型    号:MG1998-1mg

    状    态:正常点击量:69

    13501949981
    联系我?#20445;?#35831;说明是在来宝网上看到的,谢谢!

    上海迈基生物技术有限公司

    联 系 人:李学博

    电     话:021-56620378

    传     真:

    等     级: (第 1年)

    性     质:

    联系我时请说在来宝网上看到的,谢谢!




    Calcein-AM是一种可对活细胞进行荧光标记的细胞染色试剂,Calcein-AM由于在Calcein的基础上加强了疏水性,因此能够轻?#29366;?#36879;活细胞膜。当其进入到细胞质后,酯酶会将其水解为Calcein留在细胞内,发出强绿色荧光。与其它同类试剂(如BCECF-AMCarboxy-fluorescein diacetate)相比,Calcein-AM是最适合作为荧光探针去染活细胞的,因为它的细胞毒性很低。Calcein不会抑制任何的细胞功能如增殖或淋巴球的趋化性。另外,使用了Calcein的活性检测的实验结果是十分可信并且与标准的51Cr-释放法所得结果相一致的。Calcein的激发和发射波长分别为496 ?nm516 ?nm



    产品参数

    BioReagent, suitable for fluorescence
    CAS:148504-34-1
    Molecular Weight : 994.86
    Molecular Formula : C46H46N2O23
    λex 496 nm, λem 516 nm
    Purity ≥95%



    产品介绍

    Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein, which is an extremely fluorescent and negatively charged molecule. The probe can be used to stain living cells and has been observed to fluoresce bright green in cytoplasmic Schwann cells. Calcein-AM has been reported to be a neutral substrate for Mdr (P-glycoprotein (Pgp) and multidrug resistance protein (MRP)) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Studies suggest that Calcein-AM can be used to detect MDR mediated resistance and to be transported by PGP from the plasma membrane. Mitochondrial permeability research has utilized Calcein as a cytosolic fluorophore. Has been used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition.



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