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    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    商品编号:54737
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    R&D Systems流式抗体

    价    格:询价

    产    地:更新时间:2016/12/19 11:00:40

    品    牌:R&D型    号:

    状    态:正常点击量:4353

    18865410174
    联系我时,请说明是在来宝网上看到的,谢谢!

    济南鑫井医疗器械有限公司

    联 系 人:母洁洁

    电     话:0531-68629546

    传     真:0531-68629559

    等     级: (第 4年)

    性     质:生产型,

    联系我时请说在来宝网上看到的,谢谢!




    ?R&D Systems公司致力于为中国生命科学研究领域的科学家们提供研究所需要的高品质产品,满足用户的需求,从而加速中国生物制药和生命医学市场的发展,提高疾病的诊断和治疗水平,以造福全人类。R&D Systems公司产品涉及许多生命科学研究领域,如发育生物学、肿瘤研究、血液学、免疫学和神经科学等等。
    ??????R&D Systems公司提供广泛的生物素、荧光素、藻红蛋白和别藻蓝素标记的单克隆抗体,用于检测各种细胞因子和细胞因子受体,流式产品多达1200多种。主要产品有以下4类产品:
    1、胞内流式检测产品
    ??????一种简单快速的测定细胞免疫表型的方法
    2、Fluorokine? kits
    ??????如前所述,Fluorokine kits是一种极具特色的流式检测试剂,它利用了细胞因子和细胞因子受体的特异性结合,针对目前还未有抗体?#21335;?#32990;因子受体,表及相应?#21335;?#32990;因子,用于流式检测。其可以用来分析多种不同的白介素和趋化因子,如Flt-3 Ligand,G-CSF,GM-CSF,SCF,TGF-β1,TNF-α/TNFSF1A,Tpo和VEFG等。
    3、胞内流式检测产品
    ??????简单快速地鉴定分泌特定细胞因子?#21335;?#32990;,例如Th1与Th2。
    4、多色流式检测试剂盒
    ??????3-4种不同荧光标记的流式抗体;同时检测多个目标、快速&有效、一步染色,试剂盒中配有荧光标记抗体、还有多种荧光标记的对照和所有必需的缓冲液。

    R&D Systems公司的流式产品具有以下优点:

    • 覆盖范围广,涵盖胞内、胞外; ??????
    • 流式抗体效价远高于其他品牌同类产品; ??????
    • 严格质控,批次间高度一致; ??????
    • 新老科研客户的广泛认同;

      ??????与此同时,R&D Systems密切关注科研最前沿,以最快的速度、最优的质量满足科研需求。
      ??????R&D Systems为白细胞介素-17(IL-17)家族的配体和受体增添了新的荧光?#26597;?#25239;体。白介素-17 家族的配体属于促炎细胞因子,能诱发局部细胞因子的产生,并参与调节免疫功能,其中最显著的是过敏性反应。 白介素-17家族的6位成员,IL-17,IL-17B,IL-17C,IL-17D,IL-17E(也称为IL-25)及IL-17F是一组在结构上相关联的蛋白质,在氨基酸C端附近折叠成一保守的半胱氨酸结,而氨基酸N端则属于可变区。白介素-17家族成员所激活的3?#36136;?#20307;分别为IL-17受体,IL-17B 受体,和IL–17 受体C。两个被命名为IL-17 RD 及IL-17 RE的孤儿受体与IL-17受体呈现同源性,但与其相应的功能配体,?#20004;?#36824;未被人所知。
      ??????利用新的?#26597;?#25239;体,经流式细胞仪所检测出的IL-17B(图1),IL-17 C(图2)和IL-17E(图3)?#21335;?#32990;内染色如下所示。IL-17B在脊髓上有高表达, 与IL-17B 受体相结合,但不与IL-17受体相结合。

      ?


    图1、K562细胞的胞内染色,藻红蛋白标记的抗人IL-17B单克隆抗体(目录编号:IC1248P ; 填充图)与鼠IgG 28 同型对照抗体(目录编号:IC0041P ;空白图) 。
    图2 、PC - 3细胞的胞内染色,藻红蛋白标记的抗人IL-17C单克隆抗体(目录编号:IC1234P ; 填充图)与鼠IgG 28 同型对照抗体(目录编号:IC003P ; 空白图) 。
    图3 、PC - 3细胞的胞内染色,别藻蓝蛋白标记的抗人IL-17E
    单克隆抗体(目录编号:IC1258A ; 填充图)与鼠IgG 28 同型对照抗体(目录编号:IC002A ; 空白图)
    IL-17B和C已被证?#30340;?#21050;激?#35828;?#26680;细胞系THP–1,使其释放TNF-α和 IL-1?#38534;L-17B受体在炎症时表达增加,IL-17E 与IL-17B受体结合并使其激活。表1完整罗列了本公司所研发的有关白介素-17家族配体及受体所相应的荧光?#26597;?#25239;体。


    ?
    抗体列表

    目录号

    产品名称

    AF177

    Human IL-17 R Affinity Purified Polyclonal Ab

    BAF177

    Human IL-17 R Biotinylated Affinity Purified PAb

    FAB177A

    Human IL-17 R Allophycocyanin MAb (Clone 133617)

    FAB177F

    Human IL-17 R Fluorescein MAb (Clone 133617)

    FAB177P

    Human IL-17 R Phycoerythrin MAb (Clone 133617)

    MAB177

    Human IL-17 R MAb (Clone 133617)

    MAB1771

    Human IL-17 R MAb (Clone 133621)

    AF448

    Mouse IL-17 R Affinity Purified Polyclonal Ab

    BAF448

    Mouse IL-17 R Biotinylated Affinity Purified PAb

    FAB448A

    Mouse IL-17 R Allophycocyanin Affinity Purified PAb

    FAB448F

    Mouse IL-17 R Fluorescein Affinity Purified PAb

    FAB448P

    Mouse IL-17 R Phycoerythrin Affinity Purified PAb

    MAB448

    Mouse IL-17 R MAb (Clone 105828)

    AF2269

    Human IL-17 RC Affinity Purified Polyclonal Ab

    BAF2269

    Human IL-17 RC Biotinylated Affinity Purified PAb

    MAB22691

    Human IL-17 RC MAb (Clone 309822)

    AF2270

    Mouse IL-17 RC Affinity Purified Polyclonal Ab

    BAF2270

    Mouse IL-17 RC Biotinylated Affinity Purified PAb

    FAB2270A

    Mouse IL-17 RC Allophycocyanin Affinity Purified PAb

    FAB2270F

    Mouse IL-17 RC Fluorescein Affinity Purified PAb

    AF2275

    Human IL-17 RD/SEF Affinity Purified Polyclonal Ab

    BAF2275

    Human IL-17 RD/SEF Biotinylated Affinity Purified PAb

    FAB2275F

    Human IL-17 RD/SEF Fluorescein Affinity Purified PAb

    FAB2275P

    Human IL-17 RD/SEF Phycoerythrin Affinity Purified PAb

    MAB2275

    Human IL-17 RD/SEF MAb (Clone 309539)

    AF2276

    Mouse IL-17 RD/SEF Affinity Purified Polyclonal Ab

    BAF2276

    Mouse IL-17 RD/SEF Biotinylated Affinity Purified PAb

    MAB2276

    Mouse IL-17 RD/SEF MAb (Clone 400210)

    AF-317-NA

    Human IL-17 Affinity Purified Polyclonal Ab

    BAF317

    Human IL-17 Biotinylated Affinity Purified PAb

    IC3171A

    Human IL-17 Allophycocyanin MAb (Clone 41802)

    IC3171C

    Human IL-17 PerCP MAb (Clone 41802)

    IC3171P

    Human IL-17 Phycoerythrin MAb (Clone 41802)

    LUH317

    Human IL-17 Fluorokine MAP

    MAB317

    Human IL-17 MAb (Clone 41809)

    MAB3171

    Human IL-17 MAb (Clone 41802)

    AF-421-NA

    Mouse IL-17 Affinity Purified Polyclonal Ab

    BAF421

    Mouse IL-17 Biotinylated Affinity Purified PAb

    IC421F

    Mouse IL-17 Fluorescein Affinity Purified Polyclonal Ab

    IC421P

    Mouse IL-17 Phycoerythrin Affinity Purified Polyclonal Ab

    MAB421

    Mouse IL-17 MAb (Clone 50104)

    MAB721

    Mouse IL-17 MAb (Clone 50101)

    AF1248

    Human IL-17B Affinity Purified Polyclonal Ab

    BAF1248

    Human IL-17B Biotinylated Affinity Purified PAb

    BAM12481

    Human IL-17B Biotinylated MAb (Clone 174106)

    IC1248A

    Human IL-17B Allophycocyanin MAb (Clone 174113)

    IC1248F

    Human IL-17B Fluorescein MAb (Clone 174113)

    IC1248P

    Human IL-17B Phycoerythrin MAb (Clone 174113)

    MAB1248

    Human IL-17B MAb (Clone 174113)

    AF1709

    Mouse IL-17B Affinity Purified PAb

    BAF1709

    Mouse IL-17B Biotinylated Affinity Purified PAb

    AF1207

    Human IL-17B R Affinity Purified Polyclonal Ab

    BAF1207

    Human IL-17B R Biotinylated Affinity Purified PAb

    BAM1207

    Human IL-17B R Biotinylated MAb (Clone 170220)

    FAB1207P

    Human IL-17B R Phycoerythrin MAb (Clone 170220)

    MAB1207

    Human IL-17B R MAb (Clone 170220)

    MAB12071

    Human IL-17B R MAb (Clone 170216)

    AF1040

    Mouse IL-17B R Affinity Purified Polyclonal Ab

    BAF1040

    Mouse IL-17B R Biotinylated Affinity Purified PAb

    FAB1040A

    Mouse IL-17B R Allophycocyanin MAb (Clone 152316)

    FAB1040F

    Mouse IL-17B R Fluorescein MAb (Clone 152316)

    FAB1040P

    Mouse IL-17B R Phycoerythrin MAb (Clone 152316)

    MAB1040

    Mouse IL-17B R MAb (Clone 152316)

    MAB10401

    Mouse IL-17B R MAb (Clone 152309)

    AF1234

    Human IL-17C Affinity Purified Polyclonal Ab

    BAF1234

    Human IL-17C Biotinylated Affinity Purified PAb

    IC1234A

    Human IL-17C Allophycocyanin MAb (Clone 177114)

    IC1234F

    Human IL-17C Fluorescein MAb (Clone 177114)

    IC1234P

    Human IL-17C Phycoerythrin MAb (Clone 177114)

    MAB1234

    Human IL-17C MAb (Clone 177114)

    AF2306

    Mouse IL-17C Affinity Purified Polyclonal Ab

    MAB2306

    Mouse IL-17C MAb (Clone 311523)

    MAB23061

    Mouse IL-17C MAb (Clone 311522)

    AF1504

    Human IL-17D Affinity Purified Polyclonal Ab

    BAF1504

    Human IL-17D Biotinylated Affinity Purified PAb

    MAB1504

    Human IL-17D MAb (Clone 246002)

    MAB15041

    Human IL-17D MAb (Clone 246018)

    AF2274

    Mouse IL-17D Affinity Purified Polyclonal Ab

    BAF2274

    Mouse IL-17D Biotinylated Affinity Purified PAb

    IC2274A

    Mouse IL-17D Allophycocyanin MAb (Clone 312724)

    IC2274P

    Mouse IL-17D Phycoerythrin MAb (Clone 312724)

    MAB2274

    Mouse IL-17D MAb (Clone 312724)

    AF1258

    Human IL-17E Affinity Purified Polyclonal Ab

    BAF1258

    Human IL-17E Biotinylated Affinity Purified PAb

    IC1258A

    Human IL-17E Allophycocyanin MAb (Clone 182203)

    IC1258F

    Human IL-17E Fluorescein MAb (Clone 182203)

    IC1258P

    Human IL-17E Phycoerythrin MAb (Clone 182203)

    MAB1258

    Human IL-17E MAb (Clone 182203)

    AF1399

    Mouse IL-17E Affinity Purified Polyclonal Ab

    BAF1399

    Mouse IL-17E Biotinylated Affinity Purified PAb

    IC13991F

    Mouse IL-17E Fluorescein MAb (Clone 207702)

    IC13991P

    Mouse IL-17E Phycoerythrin MAb (Clone 207702)

    MAB1399

    Mouse IL-17E MAb (Clone 207710)

    MAB13991

    Mouse IL-17E MAb (Clone 207702)

    AF1335

    Human IL-17F Affinity Purified Polyclonal Ab

    BAF1335

    Human IL-17F Biotinylated Affinity Purified PAb

    IC13351A

    Human IL-17F Allophycocyanin MAb (Clone 197301)

    IC13351F

    Human IL-17F Fluorescein MAb (Clone 197301)

    IC13351P

    Human IL-17F Phycoerythrin MAb (Clone 197301)

    MAB1335

    Human IL-17F MAb (Clone 197315)

    MAB13351

    Human IL-17F MAb (Clone 197301)

    AF2057

    Mouse IL-17F Affinity Purified Polyclonal Ab

    BAF2057

    Mouse IL-17F Biotinylated Affinity Purified PAb

    IC2057A

    Mouse IL-17F Allophycocyanin MAb (Clone 316016)

    IC2057F

    Mouse IL-17F Fluorescein MAb (Clone 316016)

    IC2057P

    Mouse IL-17F Phycoerythrin MAb (Clone 316016)

    MAB2057

    Mouse IL-17F MAb (Clone 316016)


    ??????此外,安迪生物还提供一人白细胞介素-17 Fluorokine? 流式细胞仪检测试剂盒(目录编号:NF1700), 其用途为检测白细胞介素-17功能受体及估算其细胞表面密度。
    ??????IL-17多色流式检测试剂盒(目录编号:FMC007,可同时检测IL-23 R-PE 、IL-22-APC、IL-17-PerCP、CD3-CFS;图4)是R&D Systems 创新和高端品质的代表之一,深受高端科研客户?#21335;?#29233;。

    图4:?#21019;?#28608;(左?#31119;?#25110;以50ng/mL 的PMA刺激(右列)的人PBMC,用200ng/mL的?#33009;用?#32032;,10 ng/mL重组人IL-23(R&D Systems,货号#1290-IL)和500ng/mL的LPS培养过夜,?#32531;?#20197;PMA/ionomycin和3μM Monesin孵育2-4小时后,同时用CD3、白细胞介素-17和IL-22和IL-23R的抗体染色。点图顶部显示的是CD3与白细胞介素-17阳性的淋巴细胞。电图?#21335;?#37096;显示的是CD3+细胞。

    Products for Flow Cytometry from R&D Systems


    流式试剂,三重惊喜!
    1.订购1个流式多色试剂盒(货号:FMCxxx)产品,赠方形数码播放器一个。

    特别推荐畅销TH17流式多色抗体
    品名
    货号
    规格
    Human Th17 Cell 4-Color Flow Cytometry Kit
    Contains conjugated antibodies to IL-17-PerCP (Clone 41802),
    CD3-Fluorescein (Clone UCHT1), IL-22-APC
    (Clone 142928), and IL-23R-PE (Clone 218213)
    FMC007
    25 Tests
    Mouse Th17 Cell 4-Color Flow Cytometry Kit
    Contains conjugated antibodies to IL-17-PerCP (Goat IgG),
    CCR6-Fluorescein (Clone 140706), CD4-APC
    (Clone GK1.5), and IL-22-PE (Clone 140301)
    FMC008
    25 Tests

    2. 订购1个流式抗体(FABxxx,ICxxx),赠精制数码相框一个。
    特别推荐畅销胞内流式抗体
    品名
    货号
    规格
    Human IL-17 Allophycocyanin MAb (Clone 41802), Mouse IgG1
    IC3171A
    100 Tests

    特别推荐畅销胞外流式抗体
    品名
    货号
    规格
    Human VEGF R2/KDR Phycoerythrin MAb
    (Clone 89106), Mouse IgG1
    FAB357P
    100 Tests

    3. 订购1个流式辅助试剂(FCxxx),赠?#22270;?#20809;PPT翻页?#23460;?#25903;。
    品名
    货号
    规格
    Flow Cytometry Staining Buffer (500 ML)
    FC001
    500 ML
    Flow Cytometry hLyse Buffer (50 ML)
    FC002
    50 ML
    Flow Cytometry mLyse Buffer (50 ML)
    FC003
    50 ML
    Flow Cytometry Fix Buffer (100 ML)
    FC004
    100 ML
    FC Perm/Wash Buffer I (250 ML)
    FC005
    250 ML
    FC Fix/Perm Buffer I (125 ML)
    FC007
    125 ML
    FC Fix & Perm Buffer Kit I (1 KT)
    FC009
    1 KT
    FC FoxP3 Staining Buffer (1X) (250 ML)
    FC011
    250 ML

    建议订购组合:胞内流式抗体+胞外流式抗体+流式辅助试剂+流式对照抗体。研究更完整,实验更顺利!





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