• <div id="y09gn"></div>
  • <li id="y09gn"></li>
    <dl id="y09gn"></dl>
    <div id="y09gn"><s id="y09gn"></s></div>
    来宝网Logo

    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    山东博科
    现在位置首页>实验试剂制品>干细胞>干细胞试剂盒>bpsbioscience,27762-2,2-Methoxyestradiol (2-MeOE2)
    bpsbioscience,27762-2,2-Methoxyestradiol (2-MeOE2)
    bpsbioscience,27762-2,2-Methoxyestradiol (2-MeOE2)
    • bpsbioscience,27762-2,2-Methoxyestradiol (2-MeOE2)

    bpsbioscience,27762-2,2-Methoxyestradiol (2-MeOE2)

    产品报价:询价

    更新时间:2019/2/19 16:38:02

    地:美国

    牌:bpsbioscience

    号: 27762-2

    厂商性质: 生产型,贸易型,服务型,

    公司名称: 北京容圣科技有限公司

    产品关键词: 2-MeOE2   2-Methoxyestradiol   bpsbioscience   Betulinic acid  

    77
    访问人数
    0
    累计评论


    MW: 302.4 Da
    CAS Registry #: 362-07-2
    Formula: C19H26O3
    Background:
    2-Methoxyestradiol is currently in clinical trials as a therapeutic against breast and ovarian cancer. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents
    Description:
    2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in metaphase. 2-MeOE2 is also an inhibitor of tumor growth and angiogenesis. Study results have shown that 2-MeOE2 induces mammalian cell transformation and genotoxicity in Syrian hamster embryo (SHE) fibroblasts through concentration-dependent inhibition of cell growth. Moreover, 2-MeOE2 has demonstrated anti-proliferative activity against estrogen-responsive breast cancer cell line MCF-7 and subsequent inhibition of the growth of tumors subcutaneously inoculated in mice.
    Synonym(s):
    2-Methoxyestradiol; 2-MeOE2; 2-methoxy Estradiol
    Purity:
    98% purity by HPLC
    Solubility:
    Soluble in DMSO “~20 mg/ml
    Storage / Stability:

    Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

    Reference(s):
    1. Tsutsui, T., et al. Carcinogensis 2000; 21(4): 735-740. 
    2. Attalla, H., et al. Biochem. Biophys. Res. Commun. 1996; 228: 467-473.
    Scientific Category:
    Apoptosis Inducer
    Product Type:
    Activator/Inducer

     

     

    Catalog#SizeProduct Name
    27762-2100 mg2-Methoxyestradiol (2-MeOE2)
    27762-3300 mg2-Methoxyestradiol (2-MeOE2)
    27762-150 mg2-Methoxyestradiol (2-MeOE2)
    273155 mgAc-DEVD-CMK
    27733-125 mgApoptosis Activator 2
    27733-250 mgApoptosis Activator 2
    27733-3100 mgApoptosis Activator 2
    27734-3100 mgApoptosis Inhibitor
    27734-110 mgApoptosis Inhibitor
    27734-225 mgApoptosis Inhibitor
    27607-250 mgBAM7
    27607-110 mgBAM7
    27738-210 mgBendamustine HCl
    27738-15 mgBendamustine HCl
    27739-3500 mgBetulinic acid
    27739-1100 mgBetulinic acid
    27739-2200 mgBetulinic acid
    27740-125 mgBIBR 1532
    27611-325 mgBoc-D-FMK
    27611-15 mgBoc-D-FMK
    27611-210 mgBoc-D-FMK
    27741-15 mgCaspase-3/7 Inhibitor I
    27741-210 mgCaspase-3/7 Inhibitor I
    27741-325 mgCaspase-3/7 Inhibitor I
    2732110 mgCAY10625

    北京容圣科技有限公司

    | 第6

    手机:18611717737

    联系人:程园

    电话:010-57129142

    传真:010-57129142

    QQ:631767688

    (联系我时,请说明是在来宝网上看到的,谢谢!)


    云南11选5技巧
  • <div id="y09gn"></div>
  • <li id="y09gn"></li>
    <dl id="y09gn"></dl>
    <div id="y09gn"><s id="y09gn"></s></div>
  • <div id="y09gn"></div>
  • <li id="y09gn"></li>
    <dl id="y09gn"></dl>
    <div id="y09gn"><s id="y09gn"></s></div>